Home » Ask & Discuss » Biology (for Medical Entrance) » Botany « Back to Discussion

Botany

Cool goIITian

Joined:	4 Mar 2009
Post:	33

11 Oct 2009 15:56:29 IST

0 People liked this

396

what is tissue engineering?

None

what is tissue engineering?

Share this article on:

Comments (3)

miss crimson scarlet

Hot goIITian

Joined: 28 Jul 2009

Posts: 104

15 Oct 2009 07:36:37 IST

Like 1 people liked this

It is the use of a combination of cells, engineering andmaterials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, etc.).

Pramod Gupta

Scorching goIITian

Joined: 11 Jun 2008

Posts: 287

15 Oct 2009 08:45:55 IST

Like 1 people liked this

Tissue engineering / regenerative medicine is an emerging multidisciplinary field involving biology, medicine, and engineering that is likely to revolutionize the ways we improve the health and quality of life for millions of people worldwide by restoring, maintaining, or enhancing tissue and organ function. In addition to having a therapeutic application, where the tissue is either grown in a patient or outside the patient and transplanted, tissue engineering can have diagnostic applications where the tissue is made in vitro and used for testing drug metabolism and uptake, toxicity, and pathogenicity. The foundation of tissue engineering/regenerative medicine for either therapeutic or diagnostic applications is the ability to exploit living cells in a variety of ways. Tissue engineering research includes the following areas: 1) Biomaterials: including novel biomaterials that are designed to direct the organization, growth, and differentiation of cells in the process of forming functional tissue by providing both physical and chemical cues. 2) Cells: including enabling methodologies for the proliferation and differentiation of cells, acquiring the appropriate source of cells such as autologous cells, allogeneic cells, xenogeneic cells, stem cells, genetically engineered cells, and immunological manipulation. 3) Biomolecules: including angiogenic factors, growth factors, differentiation factors and bone morphogenic proteins 4) Engineering Design Aspects: including 2-d cell expansion, 3-d tissue growth, bioreactors, vascularization, cell and tissue storage and shipping (biological packaging). 5) Biomechanical Aspects of Design: including properties of native tissues, identification of minimum properties required of engineered tissues, mechanical signals regulating engineered tissues, and efficacy and safety of engineered tissues 6) Informatics to support tissue engineering: gene and protein sequencing, gene expression analysis, protein expression and interaction analysis, quantitative cellular image analysis, quantitative tissue analysis, in silico tissue and cell modeling, digital tissue manufacturing, automated quality assurance systems, data mining tools, and clinical informatics interfaces. Stem cell research - Includes research that involves stem cells, whether from embryonic, fetal, or adult sources, human and non-human. It should include research in which stem cells are isolated, derived or cultured for purposes such as developing cell or tissue therapies, studying cellular differentiation, research to understand the factors necessary to direct cell specialization to specific pathways, and other developmental studies. It should not include transgenic studies, gene knock-out studies nor the generation of chimeric animals.

edison

Forum Expert

Joined: 19 Oct 2006

Posts: 7537

29 Jan 2012 20:12:47 IST

Like 0 people liked this

Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physio-chemical factors to improve or replace biological functions. While it was once categorized as a sub-field of bio materials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells to produce tissues.

Quick Reply

Reply

	Some HTML allowed.
	Keep your comments above the belt or risk having them deleted.
	Signup for a avatar to have your pictures show up by your comment
	If Members see a thread that violates the Posting Rules, bring it to the attention of the Moderator Team