no of moles of nalorphene in 1Kg of water = 1.5 x 10^ -3
molar mass of nalorphene= 312kg mol^ -1
weight of nalorphene in 1.5 x 10^ -3 mol is = 1.5 x 10^ -3 x 312 = 0.468 g
total mass of solution is 1000.468 g
the solution required for 1.5 x 10^ -3 g of nalorphene is 1000.468/0.468 * 1.5 x 10^ -3 = 3.2 g