Addition of non-symmetrical reagent to a non-symmetrical alkene, then two isomeric products that are constitutional isomers can be obtained. For example, the reaction of HCl with propene gives 1-chloropropane and 2-chloropropane.
Normally, 2-chloropropane is the major product.
Since one product is favoured over the other, the reaction is said to be regioselective.
If 2-chloropropane were the only product then the reaction is said to be regiospecific.