steric hindrance
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as the size of alkyl group increases reactivity of reaction decreases while some time increases also.for example 3 amine are less basic than 2 amine due to steric factor because as the size of alkyl group increases reactivity decreases.reactivity of carbonyl compound towards nucleophilic addition reaction also decreases due to steric factor.HCHO>CH3CHO>CH3COCH3 | |||||||||||||
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