IIT JEE , AIEEE Forum - Chemistry , Organic Chemistry

madhusudan.chavan

Slowest step in a multi step reaction is the rate determining step. Generally it is mentioned in the reaction mechanism. While studying the mechanism we come across the r.d.s., try to remember it.
In the Hofmann bromamide reaction, the reaction is believed to occur through five steps ( one of the posting above has mentioned it). Formation of alkyl isocyanate is supposed to be the r.d.s. It has been isolated as reaction intermediate.Generally r.d.s being the slowest step it is possible to isolate the reaction intermediate (which are short lived and highly reactive). So we can infer from the intermediate which is isolated, the r.d.s.
Particularly for this reaction even the standard texts have avoided mentioning specifically the r.d.s.

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