Future Experts come here and share their knowledge base and concepts with each other. Every article submitted is reviewed by experts. Nickels are awarded to articles in terms of authenticity, relevance, clarity and presentation.
NUCLEOPHILIC SUBSTITUTION REACTIONS: . All the nucleophilic substitution reactions begins with a Heterolytic cleavage of the bond between the sp 3 carbon and the leaving group. . This bond cleavage makes the sp3 carbon electron-deficient. . With the leaving group and a pair of electrons gone, the substrate is now a positively charged carbocation . . The nucleophile then reacts with this carbocation in a heterogenic bond forming the product. Most of the Aliphatic nucleophilic substitution reactions follow one of two mechanisms
more ...
[ 1, 2
]
submitted by srujana (3192 m) on 14 Dec 2007 14:01:30 IST (30 comments 664 views)
SNi or Substitution Nucleophilic internal stands for a specific but not often encountered nucleophilic aliphatic substitution reaction mechanism. A typical representative organic reaction displaying this mechanism is the chlorination of alcohols with thionyl chloride and the main feature is retention of stereochemical configuration. Thionyl chloride first reacts with the alcohol to form an alkyl chloro sulfite. In the second step the sulfite group is lost and just like in an SN1 reaction an alkyl carbocation is created. The actual nucleophile in the third reaction step is the chlorine atom attached to the sulfite group which recombines with this carbocation. The cru
more ...
submitted by t_c511 (190 m) on 3 Apr 2007 00:04:40 IST (1 comments 107 views)
![[Avatar]](/templates/default/images/img/no-pic.gif)
