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he Sequence Rule for Assignment of Configurations to Chiral CentersAssign sequence priorities to the four substituents by looking at the atoms attached directly to the chiral center. 1.  The higher the atomic number of the immediate substituent atom, the higher the priority. For example, H?  <  C?  <  N?  <  O?  <  Cl?. (Different isotopes of the same element are assigned a priority according to their atomic mass.)2.  If two substituents have the same immediate substituent atom, evaluate atoms progressively further away from the chiral center until a difference is found.For example, CH3?  <    more ...
submitted by a4asd (310 m) on 9 May 2008 18:18:22 IST (10 comments   177 views)
 
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